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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Peramivir</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable infobox float-right" id="Vorlage_Infobox_Chemikalie" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Chemikalie">
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Strukturformel
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<tr>
<td colspan="2" class="hintergrundfarbe-basis skin-invert-image" style="text-align:center;"><span typeof="mw:File"></span>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Allgemeines
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<td style="width:33%;"><a href="Internationaler_Freiname" title="Internationaler Freiname">Freiname</a>
</td>
<td>Peramivir
</td></tr>
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<td>Andere Namen
</td>
<td>
<p>(1<i>S</i>,2<i>S</i>,3<i>R</i>,4<i>R</i>)-3-[(<i>S</i>)-1-Acetamido-2-ethylbutyl]-4-guanidino-2-hydroxycyclopentancarbonsäure <small>(<a href="IUPAC-Nomenklatur" class="mw-redirect" title="IUPAC-Nomenklatur">IUPAC</a>)</small>
</p>
</td></tr>
<tr>
<td><a href="Summenformel" title="Summenformel">Summenformel</a>
</td>
<td>C<sub>15</sub>H<sub>28</sub>N<sub>4</sub>O<sub>4</sub>
</td></tr>
<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Externe Identifikatoren/Datenbanken
</th></tr>
<tr>
<td colspan="2" style="padding:0;">
<table class="mw-collapsible mw-collapsed wikitable" data-expandtext="+" data-collapsetext="−" style="border-top:none; margin:-1px; width:calc(100% + 2px);">
<tbody><tr>
<td style="width:33%;"><a href="CAS-Nummer" title="CAS-Nummer">CAS-Nummer</a>
</td>
<td>
<ul><li><span title="Untervorlage eingebunden: CASRN"></span><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=330600-85-6">330600-85-6</a><span class="editoronly" style="display:none;"></span></li>
<li><span title="Untervorlage eingebunden: CASRN"></span><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1041434-82-5">1041434-82-5</a><span class="editoronly" style="display:none;"></span> (Hydrat)</li></ul>
</td>
<td style="background:#FFDEAD; color:#202122; border-top:1px solid #FFDEAD; padding:0.2em 0; vertical-align:bottom; width:5%;">
</td></tr>
<tr>
<td><a href="PubChem" title="PubChem">PubChem</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/154234">154234</a>
</td></tr>
<tr>
<td><a href="ChemSpider" title="ChemSpider">ChemSpider</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.135903.html">135903</a>
</td></tr>
<tr>
<td><a href="DrugBank" title="DrugBank">DrugBank</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB06614">DB06614</a>
</td></tr>
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<td style="border-right:1px solid #a2a9b1;"><a href="Wikidata" title="Wikidata">Wikidata</a>
</td>
<td colspan="2"><a href="https://www.wikidata.org/wiki/Q412734" class="extiw external" title="d:Q412734">Q412734</a>
</td></tr></tbody></table>
</td></tr>
<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Arzneistoffangaben
</th></tr>
<tr>
<td><a href="Wirkstoffklasse" title="Wirkstoffklasse">Wirkstoffklasse</a>
</td>
<td>
<p><a href="Neuraminidase-Hemmer" title="Neuraminidase-Hemmer">Neuraminidase-Hemmer</a>
</p>
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<td><a href="Pharmakodynamik#Wirkmechanismus" title="Pharmakodynamik">Wirkmechanismus</a>
</td>
<td>
<p>Hemmung der viralen Neuraminidase
</p>
</td></tr>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Eigenschaften
</th></tr>
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<td><a href="Molare_Masse" title="Molare Masse">Molare Masse</a>
</td>
<td>328,41 <a href="Gramm" title="Gramm">g</a>·<a href="Mol" title="Mol">mol</a><sup>−1</sup>
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<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Sicherheitshinweise
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<tr>
<td colspan="2">
<table cellspacing="0" cellpadding="2" style="width:100%;">
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<td colspan="2" style="text-align:center"><b><a href="Global_harmonisiertes_System_zur_Einstufung_und_Kennzeichnung_von_Chemikalien" title="Global harmonisiertes System zur Einstufung und Kennzeichnung von Chemikalien">GHS-Gefahrstoffkennzeichnung</a></b><sup id="cite_ref-SDS_1-0" class="reference"><a href="#cite_note-SDS-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
<p>Trihydrat<br>
</p>
<table class="hintergrundfarbe-neutral" style="text-align:center; margin-left:auto; margin-right:auto; display:flex; justify-content:center;">
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<td><i>keine GHS-Piktogramme</i>
</td></tr></tbody></table>
<p>
</p>
</td></tr>
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<td rowspan="2" width="33%" style="border-top:1px #A7A7A7 dashed; border-right:1px #A7A7A7 dashed;"><a href="H-_und_P-S%C3%A4tze" title="H- und P-Sätze">H- und P-Sätze</a>
</td>
<td style="border-top:1px #A7A7A7 dashed;">H: <span title="Untervorlage eingebunden: H-Sätze"></span><i>keine H-Sätze</i>
</td></tr>
<tr>
<td style="border-top:1px #A7A7A7 dashed;">P: <span title="Untervorlage eingebunden: P-Sätze"></span><i>keine P-Sätze</i><sup id="cite_ref-SDS_1-1" class="reference"><a href="#cite_note-SDS-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</td></tr>
</tbody></table>
</td></tr>
<tr>
<td colspan="2" style="background:#FFDEAD; color:#202122; font-size:80%; text-align:center; line-height:150%; padding:.25em;">Wenn nicht anders vermerkt, gelten die angegebenen Daten bei <a href="Standardbedingungen" title="Standardbedingungen">Standardbedingungen</a> (0 °C, 1000 hPa).
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Peramivir</b> ist ein <a href="Arzneistoff" title="Arzneistoff">Arzneistoff</a> aus der Gruppe der <a href="Neuraminidase-Hemmer" title="Neuraminidase-Hemmer">Neuraminidase-Hemmer</a>, der zur <a href="Therapie" title="Therapie">Therapie</a> der <a href="Influenza" title="Influenza">Grippe (Influenza)</a> eingesetzt wird.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Peramivir wirkt <a href="Virostatikum" title="Virostatikum">virostatisch</a>, indem es die virale <a href="Neuraminidase" title="Neuraminidase">Neuraminidase</a> hemmt, ein <a href="Enzym" title="Enzym">Enzym</a>, das die Freisetzung der durch Vermehrung neu gebildeten Viren aus der Wirtszelle ermöglicht.
</p><p>Peramivir unterscheidet sich von den Neuraminidase-Hemmern <a href="Zanamivir" title="Zanamivir">Zanamivir</a> und <a href="Oseltamivir" title="Oseltamivir">Oseltamivir</a> dadurch, dass es <a href="Intraven%C3%B6s" title="Intravenös">intravenös</a> verabreicht wird.
</p><p>Peramivir wurde 2014 in den USA unter dem Namen <i>Rapivab</i> zugelassen zur Behandlung akuter unkomplizierter Grippeerkrankungen.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Zuvor hatte die amerikanische Zulassungsbehörde (<a href="Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a>, FDA) Peramivir vorübergehend (von Oktober 2009 bis Juni 2010) für den Notfallgebrauch zur Behandlung der <a href="Pandemie_H1N1_2009" class="mw-redirect" title="Pandemie H1N1 2009">pandemischen Grippe H1N1 2009</a> („Schweinegrippe“) genehmigt.<sup id="cite_ref-DOI10.1056/NEJMp0910479_4-0" class="reference"><a href="#cite_note-DOI10.1056/NEJMp0910479-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Handelsnamen">Handelsnamen</h2></div>
<p><i>Rapivab</i> (USA, CA), <i>Rapiacta</i> (J), <i>Alpivab</i> (EU, a.H.)
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-SDS-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-SDS_1-0">a</a></sup> <sup><a href="#cite_ref-SDS_1-1">b</a></sup></span> <span class="reference-text">Datenblatt <span style="font-style:italic;"><a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/catalog/product/SIGMA/sml2486">Peramivir trihydrate</a></span> bei <a href="Sigma-Aldrich" title="Sigma-Aldrich">Sigma-Aldrich</a>, abgerufen am 18. Januar 2023 (<a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/DE/de/sds/SIGMA/sml2486?userType=anonymous">PDF</a>).<span class="editoronly" style="display:none;"></span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><a href="Gerd_Herold" title="Gerd Herold">Gerd Herold</a> und Mitarbeiter: <i>Innere Medizin 2023.</i> Selbstverlag, Köln 2023, ISBN 978-3-9821166-2-4, S. 876.</span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=206426"><i>NDA 206426</i></a>, FDA, abgerufen am 24. März 2023.</span>
</li>
<li id="cite_note-DOI10.1056/NEJMp0910479-4"><span class="mw-cite-backlink"><a href="#cite_ref-DOI10.1056/NEJMp0910479_4-0">↑</a></span> <span class="reference-text">Debra Birnkrant, Edward Cox: <i>The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza.</i> In: <i>New England Journal of Medicine.</i> 361, 2009, S. 2204, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1056/NEJMp0910479">10.1056/NEJMp0910479</a></span>.</span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm216252.htm">Peramivir Emergency Use Authorization Disposition Letter and Question and Answer Attachment</a></span>
</li>
</ol>
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